River Lethe is located 18 km (12 mi) west of Mount Katmai, Alaska Peninsula, and is the middle branch of the Ukak River. It flows through the Valley of Ten Thousand Smokes and meets the Ukak at .
The river was named in 1917 by R. F. Griggs, National Geographic Society; inspired by Lethe, the "river of forgetfulness" in the Hades of Greek mythology.